Flow chemistry is called in other terms such as microchemistry, plug flow or continuous flow chemistry, which is the process of performing chemical reactions inside a pipe or a tube. Reactive components in fact are being pumped together by a mixing junction and flowed down through a temperature controlled pipe or tube.
One of the big advantage when it comes to flow chemistry is on the cleaner products, fast reaction, quick reaction optimization, safer reactions, easy scale-up and also on the integration of separate process like work-up, synthesis and analysis.
There are various benefits to which flow chemistry could actually give. Another thing is that this comes with faster reactions and that the reactors are easily pressurized. This is going to allow reactions for it to be heated above the normal boiling point that creates reaction rates that are thousands times much faster. This kind of process is called as superheating.
Finding Parallels Between Help and Life
Flow reactors also enable excellent reaction selectivity. Rapid diffusion mixing helps to avoid problems that are found in batch reactors. A high surface area to volume rations enable almost an instantaneous heating or cooling which later on leads to an ultimate temperature control.
Smart Tips For Uncovering Resources
Flow chemistry also allows only a small amount of hazardous intermediate in forming any time in an instant. A high surface area likewise allow excellent control to exotherms.
This also has an integrated synthesis, work-up and analysis as well. The reaction products exiting a flow reactor can possibly be flowed to a flow aqueous work-up system or maybe to a solid phase scavenger column. From there, it could then be analyzed in a line or through a sample taken using a sampler and a dilutor then injected to the LCMS.
Flow chemistry also has rapid reaction optimization. Flow chemistry that comes with automation enables quick variation on reaction conditions on a small scale. Parameters such as ration of reagents, temperature, reaction time, concentration and reagents themselves could all be varied rapidly. One single reaction could in fact follow another, separated by solvent each of them cleaning out the previous reaction.
Flow chemistry have easy scale-up as well. The scale up issues are in fact being minimized due to maintaining an excellent mixing and heat transfer. High flow rates and the larger reactors can in fact be used to easily produce kilogram quantities.
Using microreactor technology, it is able to speed up more the development and its up-scaling in a much faster way. The microreactors are in fact devices that are operating through a continuous flow that allows strict control of the reaction parameters to be able to control reactions which are otherwise hazardous, reactive or are exothermic. In order to get significant amounts of such product, microreactors are not scaled up but the internal volumes of the actual channels are being increased by its smart mechanical design and also the reactors are being numbered up.